Acute Generalized Exanthematous Pustulosis Caused by Daptomycin

Acute Generalized Exanthematous Pustulosis Caused by Daptomycin

Daptomycin, a lipopeptide antibiotic with similar action as vancomycin, is used to treat complicated skin and soft tissue infections caused by resistant Gram-positive bacteria, including methicillin-resistant Staphylococcus aureus, penicillin-resistant streptococci, and vancomycin-resistant enterococci. Acute generalized exanthematous pustulosis (AGEP), characterized by acute onset of numerous ...

Acute generalized exanthematous pustulosis caused by diltiazem.

Acute generalized exanthematous pustulosis is clinically characterized by fever, pruritus and an acute pustular eruption. It can be described as having an abrupt onset and then spontaneous resolution occurs shortly after the start of symptoms, and there is usually only a single episode. Most cases have been triggered by the ingestion of drugs. Diltiazem hydrochloride is a calcium channel blocke...

Acute generalized exanthematous pustulosis

Acute localized exanthematous pustulosis caused by flurbiprofen.

To the Editor: Acute generalized exanthematous pustulosis (AGEP) is an acute skin reaction that is characterized by generalized, nonfollicular, pinhead-sized, sterile pustules on an erythematous and edematous background. The eruption can be accompanied by fever and neutrophilic leukocytosis. Skin symptoms arise quickly (within a few hours), most commonly following drug administration. The medic...

Acute generalized exanthematous pustulosis induced by simvastatin.

Acute generalized exanthematous pustulosis is an acute pustular eruption occurring most commonly after drug ingestion. It is a self-healing condition with spontaneous cure after discontinuation of the causative drug. We report the second case, as far as we know, of acute generalized exanthematous pustulosis induced by simvastatin intake. Conclusion: simvastatin can be included on the long list ...